Heterologous protection with Ingelvac PRRS MLV. More than 20 years protecting against old and emerging PRRSV strains

Germany

• Eradication of PRRS in a breeding herd : According to serological and virological diagnostic results the eradication appears to be successful. The negative PCR result in all samples tested is the most important confirmation of success.
• Carbopol improves the early cellular immune responses induced by the modified-life vaccine Ingelvac PRRS MLV :
• PRRS-stabilisation of a 6000 sow herd by mass vaccination : With progressing stabilisation of the herd lossesin the nursery further decreased. The following parameters were significantly improved also: Repeat service rate, Number of live born piglets, Preweanig mortality, Number of weaned piglets/litter.
• Eradication of PRRSV from a closed pig herd : Due to the immediate vaccination programme following the PRRSV outbreak, an immediate and stable immunity withinthe whole herd was established by which the PRRS fieldvirus was successfully eliminated from the herd.
• The use of Ingelvac PRRS - MLV for herd specific elimination of PRRSV from piglets born to a PRRSV-positive sow population : Ingelvac PRRS MLV was shown to reduce European PRRSV field strains from infected populations significantly. In distinct herds with well control health management and production systems, PRRSV could be eliminated from piglets produced from sows vaccinated
• Efficacy of Ingelvac® PRRS MLV against European isolates : A single dose of the Ingelvac® PRRS modified live vaccine significantly reduced piglet loss after both heterologous European virus challenges.

United States

• Impact of a modified-live PRRSV vaccine intervention on a population of pigs infected with a heterologous isolate : Impact of a modified-live porcine reproductive and respiratory syndrome virus vaccine intervention on a population of pigs infected with a heterologous isolate
• Efficacy of Ingelvac PRRS MLV against a heterologous PRRSV 1-7-4 RFLP challenge :
• Efficacy of a modified live porcine reproductive and respiratory sydrome virus vaccine against heterologous virulent Lelystad challenge : In conclusion, this summary confirms the ability of a modified live PRRS vaccine (Ingelvac® PRRS MLV) to provide heterologous protection following virulent challenge with the European LV strain of PRRS.
• Use of Ingelvac® PRRS MLV to stabilize a farrow-to-finish herd dually infected with both NA and EU PRRS field strains : The consequences of a PRRS infection for this farm go beyond the standard implications.

Malaysia

• Impact of stopping PRRS MLV vaccination in piglets in a malaysian farm : All in all, a long term whole herd PRRS MLV vaccination approach is vital to reduce the losses in the farm due to PRRS infection.
• Effect of Ingelvac® PRRS MLV on boar semen quality in an endemic farm : Based on this field experiment, we can conclude that Ingelvac PRRS MLV is safe to use in PRRS-positive boar.

China

• Influence of Ingelvac® PRRS MLV vaccination on variability of S/P values serology in a breeding herd : Breeding herd stability can be defined as a cessation of PRRS virus circulation in the breeding herd. This is an important milestone in a PRRS control program.

South Korea

• Concurrent vaccination of boars with type 1 and type 2 porcine reproductive and respiratory syndrome virus (PRRSV) : The results demonstrate that concurrent vaccination of boars with type 1 and type 2 PRRSV reduces shedding of both genotypes in semen
• Evaluation of a 20 year old PRRS modified live vaccine (Ingelvac PRRS MLV) against two recent type 2 PRRS virus isolates in South Korea : Evaluation of a 20 year old porcine reproductive and respiratory syndrome (PRRS) modified live vaccine (Ingelvac PRRS MLV) against two recent type 2 PRRS virus isolates in South Korea

United States

• Comparison of Host Immune Responses to Homologous and Heterologous Type II PRRSV Challenge in Vaccinated and Unvaccinated Pigs : Comparison of Host Immune Responses to Homologous and Heterologous Type II Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) Challenge in Vaccinated and Unvaccinated Pigs
• Pig vaccination as an essential part of a comprehensive PRRS control program : Consistently inducing uniform population immunity among vaccinated groups of pigs is believed to be a key to the success of this comprehensive approach to PRRS control.

South Korea

• Case report: Growing performance improvement after using PRRS MLV at 3 weeks old piglets in a Korean swine farm : After the implementation of Ingelvac® PRRS MLV piglet vaccination, PRRS stabilization was achieved and an overall improvement in productivity was observed.

Japan

• Efficacy of vaccination of Ingelvac® PRRS MLV in pigs in Japanese farrow-to-finish farm : The key of succession of PRRS vaccination is that confirming by monitoring that there is no vertical/horizontal transmission of PRRS virus before weaning and when the field exposure of PRRS virus was occurred.
• Efficacy of Type 2 PRRSV vaccine against the 2010 isolate of Vietnamese highly pathogenic PRRSV challenge in pigs : Efficacy of Type 2 porcine reproductive and respiratory syndrome virus (PRRSV) vaccine against the 2010 isolate of Vietnamese highly pathogenic PRRSV challenge in pigs

South Korea

• Vaccination with Ingelvac PRRS® MLV for PRDC control in Korean swine farm : PRRS MLV vaccination is an important part of the solution when PRRS is involved in a PRDC problem. A strategy of PRRSV MLV vaccination at 3-4 weeks before PRRSV infection is a promising method for providing sufficient immunity to pigs against PRRSV.
• Vaccination with PRRS type 2 strain against high pathogenic type 1 virus in growing pigs in Korea : In this study, it is concluded that a Type 2 strain based modified live vaccine could reduce the impact of the highly pathogenic PRRS wild type 1 virus. This is consistent with other researchers’ findings.
• Effect of vaccination with a modified live PRRSV vaccine on growth performance in fattening pigs under field conditions : Effect of vaccination with a modified live porcine reproductive and respiratory syndrome virus vaccine on growth performance in fattening pigs under field conditions

China

• Experience of controlling PRRSv in an 1800-head sows farm in Southern China : This study demonstrates that Ingelvac® PRRS MLV was an effective measure to control PRRSV. It also demonstrates that Ingelvac® PRRS MLV is cross protective to HP-PRRSV strains which was also shown previously.
• Successful control of HP PRRS with INGELVAC® PRRS MLV in a 3500-sow pig farm in North China : This case report has proven that Ingelvac® PRRS MLV was effective in reducing the clinical signs and the mortality caused by HP PRRS virus in field. This is comparable to a previous field control case.
• Efficacy of Ingelvac®PRRS MLV on HP PRRS control in a farm of Northeast China : In this control case, after confirming PRRS infection, the use of Ingelvac®PRRS MLV proved to be effective in reducing both morbidity and post-weaning mortality as well as days to market.
• Efficacy of Type 2 PRRSV vaccine against Chinese and Vietnamese HP-PRRSV challenge in pigs :
• Immunization of pigs with a type 2 modified live PRRSV vaccine prevents the development of a deadly long lasting hyperpyrexia : Vaccination did not prevent infection, but reduced the impact of clinical disease and prevented hyperpyrexia associated mortality.
• Effect of vaccination of Ingelvac® PRRS MLV in a 860-sow farm in East China : After the evaluation of the trial the farm started to use Ingelvac® PRRS MLV in sows (mass vaccination of all breeding animals every 3 month) and pigs (vaccination at 10 days of age) as a tool to control PRRS.

Mexico

• Seriological evaluation of two different schemes of mass herd vaccination using modified live vaccine (MLV) in a PRRSV control program : The results of this study show the efficacy of mass herd vaccination to stabilize the sow herd and to production of naïve weaned pigs, allowing a better assessment of control tools of PRRSV in growing pigs.
• Observations of sustained PRRS control by modified-live vaccination of sows and pigs : The modified-live PRRSv vaccination program resulted in sustained, acceptable PRRS control in the breeding herd and post-weaning pig production.
• Evaluation of two vaccination programs against PRRS virus, PCV2 and Mycoplasma hyopneumoniae in a swine production system in Mexico : The economic benefit of 3FLEX in comparison to the identical but separately administered vaccines can at least partly be assigned to the reduction of stress caused by multiple handling and injections.
• Measuring PRRSV reproductive outbreak severity in 3 naïve herds through statistical process control chart - CUSUM using MLV as an intervention tool : CUSUM charts are useful tools to detect cumulative deviations from the target; this SPC monitoring showed a potential benefit minimizing the severity and duration of PRRSv outbreaks in farms B and C using MLV vaccine as a contingency vaccine.

China

• Efficacy of Ingelvac PRRS MLV on HP PRRS in a Chinese Pig Farm : Ingelvac® PRRS MLV vaccination program and health management are essential to achieve good performance in PRRS positive farms.
• Successful control of Porcine High Fever Disease in a Chinese 1200 sow farm: a case report : In conclusion, Ingelvac® PRRS MLV is a useful tool to control and prevent PHFD.

Thailand

• Comparison efficacy of Type I and Type II PRRS vaccine in Thai commercial farm : The results of this study demonstrated poor efficacy performance using Type I vaccine in the farm positive for PRRSV type II compared to a VR2332 based vaccine.
• Efficacy comparison of 2 different PRRS MLV type 2 vaccines in a commercial farm in Thailand : The results of this study demonstrated that Ingelvac® PRRS MLV vaccine had a significantly better efficacy in grower-finisher pigs.
• Comparison of PRRS MLV type2 vaccine efficacy of Pre-farrow vaccination program and Mass vaccination program in Thai swine farm : Consistent implementation of strategic sow herd mass vaccination program using Ingelvac PRRS MLV vaccine for control of PRRSv infections was effective in improving sow performance and reducing pre-weaning mortality.
• The impact of discontinuing PRRS MLV vaccination in piglets in the single site farm in Thailand : Based on the mortality change, stopping PRRS MLV vaccination resulted in big economic loss in this farm. The benefit-to-cost ratio between non-vaccinated and vaccinated is 7.03:1 based on the mortality alone.

Philippines

• Case control and management of virulent PRRS in a commercial farm in the Philippines : Despite dramatic improvements, the farm is still a case-control in progress, vaccinating with lngelvac PRRS MLV just barely 6 months as of data avallability.

Vietnam

• Long term and sustainable protection against PRRSV in a commercial farm in Vietnam using Ingelvac® PRRS MLV : These results confirmed the efficacy of Ingelvac® PRRS MLV in preventing HP-PRRS negative impact under Vietnam conditions in a sustainable manner.