Efficacy of Ingelvac® PRRS MLV in Korean swine farm with PRRSV co-infection (EU&NA Types)

In this study, we evaluated the efficacy of Ingelvac® PRRS MLV piglet vaccination in a Korean swine farm that co-infected with PRRSV-1 and PRRSV-2.

11-06-2018


Article by:

SW Lee1, BS Kang, SY Kang2

1 Boehringer Ingelheim Vetmedica Korea Ltd; 2 Virology Laboratory, Veterinary medicine, Chungbuk National University, Korea

Introduction

Porcine reproductive and respiratory syndrome virus (PRRSV) causes respiratory disease in nursery and grow-finisher pigs and reproductive failure in sows and boars1. PRRSV-infected pigs usually suffer from poor growth performance and are highly susceptible to co- or secondary bacterial and other viral infections2.
PRRSV was first isolated in Korea in 1994 and all PRRSV isolates corresponded to genotype 2 (PRRSV-2) until 2000, genotype 1 (PRRSV-1) has recently emerged in Korea3.
In this study, we evaluated the efficacy of Ingelvac® PRRS MLV piglet vaccination in a Korean swine farm that co-infected with PRRSV-1 and PRRSV-2.

Materials and methods

This study was conducted in a commercial 1,700 sows, farrow to finisher farm. In 2016, this farm has experienced a negative impact in productivity due to co- infection with PRRSV-1 and PRRSV-2. We decided to execute a control program for the main pathogens involved trough piglet vaccination with Ingelvac® PRRS MLV.
In December 2016, this farm implemented a systematic breeding herd mass vaccination with Ingelvac® PRRS MLV (2ml) two times 4 weeks apart followed by quarterly mass vaccination (every 3 months). At the same time, piglet vaccination was performed with Ingelvac® PRRS MLV (2ml) at 3 weeks of age.
Before/After vaccination, blood samples were taken for examination by ELISA(IDEXX PRRS 3X) and RT-PCR to determine the presence of PRRS antibody and antigen. Also the performance data were analysed before and after vaccination period.

Results

Prior to vaccination, both PRRSV-1 and PRRSV-2 was detected in piglets (Table1). And there was rapid increase in PRRSV antibody titer after weaning (Figure1). After piglet vaccination PRRSV-2 was detected only late nursery andthe variability of SP values was reduced, suggesting a better stabilization process (Table1, Figure 1). Performance was improved after vaccination (Figure 2). Average growth rate was 8.2 % higher in the vaccine intervention period (86.7 % vs 94.9 %).

Table 1. PRRSV antigen detected.

Table 1. PRRSV antigen detected.

Figure 1. PRRS antibody titer

Figure 1. PRRS antibody titer

Figure 2. SPC Chart of Growth rate after weaning

Figure 2. SPC Chart of Growth rate after weaning

Conclusion

According to the results of this report, it can be concluded that the implementation of a systematic vaccination program with Ingelvac® PRRS MLV in piglets and quarterly mass vaccination of the breeding herd with Ingelvac®PRRS MLV was successful controlling PRRSV co-infection( genotype 1 & 2) resulting in significantly reduction of wean to finish mortality. Considering these results, we propose that this vaccination program can be implemented in other farms with similar PRRSV problems.

References

1. Zimmerman, J., et al. (2006).Disease of swine. p. 387-417
2. Lunney JK et al. Virus Res. 2010;154:1-6.
3. Kiwon Han., et al. (2011). Clinical and Vaccine Immunology. P. 1600-1607

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2018