Vaccinatie

Boehringer Ingelheim vaccines deliver sustainable, whole-herd PRRS control through all phases of production. Boehringer Ingelheim has multiple modified-live vaccines for PRRS, which have demonstrated cross-protection for both the reproductive and respiratory forms of the disease. When determining a vaccine protocol, it is important to use the right vaccine at the right place and time.

BENEFITS OF VACCINATION
 
Multiple controlled and field-based studies have demonstrated that Ingelvac PRRS® vaccines provide two benefits to producers:
1.     Direct benefit – The effects of infection are reduced and there is a subsequent improvement in health and performance.
2.     Indirect benefit – Studies show that Ingelvac PRRS® vaccines can reduce shedding/transmission of wild-type PRRS virus.
 
DIRECT BENEFIT
 
Pigs challenged with the PRRS virus experience lower average daily gain and higher mortality rates, with an estimated profit loss of $4.32 per pig.1 However, extensive controlled and field-based studies have demonstrated that Ingelvac PRRS® vaccines provide a direct benefit to pigs and producers, including:
·       Cross-protection against a variety of field strains2,3,4,5
·       Reduced mortalities1,6
·       Improved average daily gain1,6
 
To help ensure ongoing benefits, Boehringer Ingelheim Vetmedica, Inc. continues to evaluate the effectiveness of Ingelvac PRRS® MLV against the most current strains of PRRS virus to provide you with up-to-date information.
 
INDIRECT BENEFIT
In addition to reducing clinical disease, studies demonstrate that Ingelvac PRRS® MLV can provide an indirect benefit by reducing shedding/transmission of wild-type PRRS virus.
In a study comparing pigs vaccinated with Ingelvac PRRS® MLV to non-vaccinated controls, vaccinated pigs had a significant reduction in the frequency of wild-type virus shedding (measured by virus detected in the air) and a 30-day shorter duration of shedding compared to the non-vaccinated pigs.7
Dr. Scott Dee (Pipestone Veterinary Services) discussed the impact of PRRS transmission and the benefits of reduced shedding. Watch to learn more.
References
Holtkcamp, D, Kliebenstein JB, Neumann EJ, et al. 2013. Assessment of the economic impact of porcine reproductive and respiratory syndrome virus on United States pork producers. J Swine Health Prod 2013:21(2): 72–84.
Roof M, et al. Efficacy of modified-live virus porcine reproductive and respiratory virus vaccines against heterologous respiratory challenge. 2003, IPVS, p. 117.
Jordan D, Layton S, Philips R, Genzow M. Modified-live PRRS vaccination provides heterologous protection against virulent 1-18-2 challenge. 2009. Leman Conference.
Roof MB, Vaughn E, Rurkhart K, Johnson W. Meta-analysis of 16 modified-live PRRS vaccination challenge studies. International Symposium of Emerging and Reemerging Swine Diseases, 2007.
Patterson A, Victoria J, Jordan D, et al. Modified-live PRRSv vaccination is efficacious following challenge with eight genetically diverse PRRSv isolates. Leman Conference, 2013.
Oropeza A, Kolb J, Philips R, and White M. A summary of three large-scale systems-based PRRS control projects.
7 Wetzell T, Cano J, Rustvold J. Reduction of Wild-Type PRRS Virus Shedding in Aerosol of Growing Pigs by Modified-Live Virus Vaccination at Weaning. 2013 Pipestone Research Committee, Leman Conference, p. 196.
 
Reducing aerosol shedding of PRRS virus with MLV vaccine
Pigs raised in swine-dense areas are potentially at a greater risk of being infected with porcine reproductive and respiratory syndrome (PRRS) due to aerosol shedding of PRRS virus.1 Implementing strategies to reduce aerosol transmission of PRRS virus is important to reduce the shedding of PRRS virus within and between herds to minimize the risks of breaks or re-breaks of herds.
 
Research has been conducted to evaluate shedding of wild type (wt) virus in pigs vaccinated with Ingelvac PRRS® as compared to non-vaccinates.2,3,4 A recent study evaluated both the duration and frequency of aerosol shedding in pigs infected with PRRSv 29 days following vaccination with Ingelvac PRRS® compared to non-vaccinated pigs.4 The period between the first and last positive aerosol samples was 36 days for the non-vaccinated barn, and only 6 days for the vaccinated barn. Additionally, the total number of positive sampling days during the 118-day trial was 21 for the non-vaccinated barn and only 4 days for the vaccinated barn (see below).
 
The barn with pigs vaccinated with Ingelvac PRRS® had 17 fewer positive aerosol days and 30 days’ shorter total shedding period compared to the non-vaccinated barn.
 
Reducing both the duration and frequency at which infected pigs shed wt PRRS virus can help minimize the chances of aerosol spread of the virus within a region. Talk to your Boehringer Ingelheim Vetmedica, Inc. representative to discuss how Ingelvac PRRS® vaccines can help your herd.
 
References
1. Mortensen S, Stryhn H, Søgaard R, et al. Risk factors for infection of sow herds with porcine reproductive and respiratory syndrome (PRRS) virus. Prev Vet Med 2002;53(1–2):83–101.
2. Cano JP, Dee SA, Murtaugh MP, Pijoan C. Impact of a modified-live porcine reproductive and respiratory syndrome virus vaccine intervention on a population of pigs infected with a heterologous isolate. Vaccine 2007;25(22):4382–4391.
3. Linhares DC, Cano JP, Wetzell T, et al. Effect of modified-live porcine reproductive and respiratory syndrome virus (PRRSv) vaccine on the shedding of wild-type virus from an infected population of growing pigs. Vaccine 2012;30(2):407–413.
4. Wetzell T, Cano J, Rustvold J. Reduction of Wild-Type PRRS Virus Shedding in Aerosol of Growing Pigs by Modified-Live Virus Vaccination at Weaning. 2013 Pipestone Research Committee, Leman Conference, p. 196.
VACCINATION RECOMMENDATIONS
 
BREEDING HERD TESTED AT WEANING (POS/NEG)* GROW-FINISH EXPOSURE VACCINATE BREEDING HERD FOR PRRS? VACCINATE GROWING PIGS FOR PRRS?
+
(Positive and unstable)
+ + YES
(attain stability)
YES**
+
(Positive and stable)
+ YEYS
(maintain stability)
YES
+
(Positive and stable)
YES
(maintain stability)
NO

(Negative)
+ Not Recommended YES

(Negative)
Not Recommended NO
 
*PRRS PCR assessment of pigs at weaning.
**Studies demonstrate the benefit of vaccinating growing pigs when PRRS virus prevalence is low
(<20% positive PCR pools). This decision should be made under the direct consultation of a veterinarian.1,2
 
Gilts should be vaccinated twice — 30 days apart — with the last dose occurring four weeks prior to entry into the breeding herd.
 
Always work with your herd veterinarian when developing vaccination protocols. Read and follow label directions.
 
*PRRS PCR assessment of pigs at weaning.
**Studies demonstrate the benefit of vaccinating growing pigs when PRRS virus prevalence is low
(<20% positive PCR pools). This decision should be made under the direct consultation of a veterinarian.1,2
References:
1 Waddell J. et al. Modified-live PRRS virus vaccination of nursery pigs as an essential component of a comprehensive PRRS control program. IPVS, 2008.
2 Boehringer Ingelheim Vetmedica Inc., internal data. Unpublished at this time.